Distance from Humble, Kentucky to St. Louis, Missouri
The driving distance from Humble, Kentucky to St. Louis, Missouri is 366.5 mi (589.8 km)
The straight-line (air) distance is approximately 186.1 mi (299.4 km)
Estimated travel time by road is 5 hours 36 minutes
We found 3 routes between Humble and St. Louis.
Available Routes
Route Directions
Get on Cumberland Pkwy in Russell Springs
Follow Cumberland Pkwy, I-65 S and I-165/KY-9007 N to KY-54 W/E Parrish Ave in Daviess County. Take exit 18 from US-231 N/US-60
Get on I-69 in Ohio Township from IN-161 N, IN-66 W and Ohio River Scenic Byway
Follow I-64 W to Clark Ave/Old Rte 66 E in St. Louis. Take exit 40A from I-64 W
Follow Clark Ave and S Tucker Blvd to your destination
Route Directions
Get on Cumberland Pkwy in Russell Springs
Continue on Cumberland Pkwy. Drive from I-65 S, I-165/KY-9007 N and KY-9005/Audubon Pkwy to Henderson County. Take exit 10B from US-41 S
Get on I-64 W in Pendleton Township from US-60 W, KY-56 W, IL-13 W and State Rte 142
Follow I-64 W to Clark Ave/Old Rte 66 E in St. Louis. Take exit 40A from I-64 W
Follow Clark Ave and S Tucker Blvd to your destination
Route Directions
Take KY-80 W, KY-55 N, KY-210 and Lincoln Pkwy to Western Kentucky Pkwy in Elizabethtown
Continue on Western Kentucky Pkwy to Elizabethtown Bypass. Take exit 136 from Western Kentucky Pkwy
Get on I-64 W in Harrison Township from KY-1600 N, KY-313 and IN-135 N
Follow I-64 W to Clark Ave/Old Rte 66 E in St. Louis. Take exit 40A from I-64 W
Follow Clark Ave and S Tucker Blvd to your destination
Journey Details
Traveling from Humble, Kentucky to St. Louis, Missouri covers 359.2 miles (578 km) in a west direction. This highway, long-distance route typically takes 5 hours 54 minutes under normal conditions.
Drivers have 3 route options between these locations (359-376 miles / 578-604 km). The primary route shown here saves 5 minutes compared to alternatives.
The route features scenic views. During night weekday travel, expect minimal traffic congestion with average speeds around 63 mph (101 km/h) .
Journey Waypoints
Humble
Starting Point
St. Louis
Destination
