Distance from Manokin, Maryland to Mayo, South Carolina
The driving distance from Manokin, Maryland to Mayo, South Carolina is 608.6 mi (979.5 km)
The straight-line (air) distance is approximately 247.3 mi (398 km)
Estimated travel time by road is 9 hours 19 minutes
We found 3 routes between Manokin and Mayo.
Available Routes
Route Directions
Get on US-50 W in Queen Anne's County from US-13 N
Follow I-95 S and I-85 S to SC-110 N in Spartanburg County. Take the SC-110 exit from I-85 S
Take Mayo Rd/State Rd S-42-105 to US-221 S in Mayo
Route Directions
Get on I-64 E in Norfolk from US-13 S
Take I-264 W and US-13 S to US-58 W in Suffolk
Get on I-95 S in Emporia
Continue on I-95 S. Take US-64 W and I-87 to US-64 W in Cary. Take exit 98B from US-1 S/US-64 W
Get on US-421 N in Chatham County
Take I-85 S to SC-110 N in Spartanburg County. Take the SC-110 exit from I-85 S
Take Mayo Rd/State Rd S-42-105 to US-221 S in Mayo
Route Directions
Get on I-64 E in Norfolk from US-13 S
Take I-264 W and US-13 S to US-58 W in Suffolk
Get on I-85 S in South Hill
Follow I-85 S to SC-110 N in Spartanburg County. Take the SC-110 exit from I-85 S
Take Mayo Rd/State Rd S-42-105 to US-221 S in Mayo
Journey Details
Traveling from Manokin, Maryland to Mayo, South Carolina covers 505.6 miles (814 km) in a southwest direction. This highway, long-distance route typically takes 8 hours 13 minutes under normal conditions.
Drivers have 3 route options between these locations (506-609 miles / 814-979 km). The primary route shown here saves 1 hour and 7 minutes compared to alternatives.
The route features scenic views, toll sections. During midday weekend travel, expect typical weekend traffic patterns with average speeds around 64 mph (103 km/h) .
Journey Waypoints
Manokin
Starting Point
Mayo
Destination
